Addressing Accuracy and Precision Issues in iTRAQ Quantitation

Addressing accuracy and precision issues in iTRAQ quantitation.

iTRAQ (isobaric tags for relative or absolute quantitation) is a mass spectrometry technology that allows quantitative comparison of protein abundance by measuring peak intensities of reporter ions released from iTRAQ-tagged peptides by fragmentation during MS/MS. However, current data analysis techniques for iTRAQ struggle to report reliable relative protein abundance estimates and suffer with...

AccucheckInform II: About Its Accuracy and Precision

Developing a Method for Increasing Accuracy and Precision in Measurement System Analysis: A Fuzzy Approach

Measurement systems analysis (MSA) has been applied in different aspect of industrial assessments to evaluate various types of quantitative and qualitative measures. Qualification of a measurement system depends on two important features: accuracy and precision. Since the capability of each quality system is severely related to the capability of its measurement system, the weakness of the two...

Addressing issues in letter recognition.

The present research strategy utilizes factorial designs, functional measurement, testing of mathematical models and strong inference in the study of letter perception. To test the viability of this framework, subjects judged a number of ambiguous letters, varying between Q and G, in both a rating and discrete choice task. The letters were created by varying features of openness in the oval and...

Addressing Fundamental Issues

Kuhn and Dean (this issue) make a valuable contribution to the challenge of increasing the scientific reasoning skills of lowperforming urban sixth graders. They describe a procedure that was highly effective in the short run, and they show how difficult it is to achieve long-term transfer with anything less than extremely detailed and direct instruction. In addition, their work raises importan...